Atip Avenir Program 2012 KiaThis response is initiated by the perception of pathogen- derived signatures referred to as Pathogen or Microbe associated molecular patterns (PAMPs or MAMPs). Both plants and animals sense PAMPs and in turn differentially regulate a large set of immune responsive genes, among which micro. RNA (mi. RNAs) were recently identified. These small regulatory RNAs control gene expression mostly at the post- transcriptional level by inducing degradation and/or translational silencing of target m. RNAs. Lionel Navarro and his laboratory recently showed that growth of a type III secretion- defective mutant of Pseudomonas syringae as well as non- pathogenic bacteria was significantly enhanced in Arabidopsis mi. RNA- deficient mutants, implicating the mi. RNA pathway as major component of antibacterial defense. Accordingly, we have identified P. Their goal is now to identify the modes of action of these bacterial silencing suppressors and to determine whether analogous mechanisms of RNA silencing suppression are used by human pathogenic bacteria. Role of the RNA- directed DNA methylation pathway in the regulation of the Arabidopsis immune response and the evolution of immune- response genes. In higher eukaryotes, the vast majority of the genome appears to be transcribed, leading to an extraordinary diversity of non- coding RNAs (nc. RNAs). Whereas the functional significance of these nc. Our Partners Custom link to a. ATIP-Avenir program of the CNRS-INSERM” as well as international organizations. Julien Dumont started his own independent CNRS research team at Institut Jacques Monod in 2012. 1 National Research Agency (ANR). Chairmanship of the Belmont Forum since 2012. A cooperative company of public interest. In 2011/2012, in a team with Anne. The admirable Atip-Avenir program of CNRS/Inserm goes a long way to improve the situation. The ATIP-Avenir funding may be extended for an extra two years after. 2012 selected applicants (17.5 ko) 2011 selected. RNAs is mostly unknown, increasing evidence suggests a role for these molecules in guiding chromatin modifications. In plants, a large proportion of nc. RNAs is processed by the RNA silencing machinery to produce short interfering (si)RNAs. Some of them guide sequence specific DNA methylation through a phenomenon referred to as RNA- directed DNA methylation (Rd. DM). The Rd. DM pathway contributes to the transcriptional silencing (TGS) of transposons, repeats as well as some genes that carry repeats in their vicinity. Lionel Navarro and his team have recently shown that DNA demethylation is part of a plant immune response and, accordingly, have identified functionally relevant defense genes that are directly controlled by this epigenetic regulatory mechanism. Their goal is now to determine whether bacterial effectors could have evolved strategies to interfere directly with the Arabidopsis TGS machinery to enable disease. They are also investigating the contribution of the Rd. DM pathway in transgenerational immune priming and its eventual implication in the evolution of immune- response genes. Mathieu Gabut - CV - Ph. D Biochemistry and Cellular Biology. Course and current status. Education and training. Atip- Avenir program laureate. Principal Investigator: . Best Foundation Postdoctoral fellowship (Canada). Doctoral fellowship from the French Ministry for Education and Research (France). Programme ATIP-AVENIR 2013 – Date limite 29/11/2012. Dans le cadre d’un partenariat, l’Inserm et le CNRS lancent un appel d’offres pour : permettre ATIP-AVENIR program: Promotion of young researchers. Under a partnership between Inserm and CNRS, a call for proposals is launched to: Enable young scientists to create and lead a team within an already existing structure. Under a partnership between Inserm and CNRS, a call for proposals is launched aimed at: Enabling young scientists to create and lead a team within an established laboratory in France. The ATIP - Avenir teams will strengthen. 2012 NIH International Opportunities Expo Special Edition. Contributing to global science development by building careers. Editorial: 2012 Expo in a Glimpse: An Introduction for the 2014 Expo! ATIP-Avenir Program – Applicant’s guide DESP/CG/DV 1 ATIP – Avenir Program 2013 Applicant’s guide Important dates: - November 29 th 2012: deadline for the online submission, the mailing of the hard copy of the. ERASMUS Student grant (France and Sweden). Scientific summary. Our current research is aimed at identifying factors and signalling pathways which control the functional diversity of the transcriptome underlying gene expression programs that support the of stem cells fate. More specifically, we are investigating the role and regulation of alternative splicing, a key step of m. RNA maturation and a power mechanism generating m. RNA and proteomic diversity, for the control of stem cell identity. Using high- throughput technologies (splicing microarrays and RNA- seq), we are focusing on two models: 1- we study the role of alternative splicing programs (co- regulated splicing events) for the maintenance of mouse embryonic stem cell fundamental properties (self- renewal and pluripotency). Our recent work identified a novel and conserved splicing event for the transcription factor FOXP1 which acts as a switch on stem cell fate, either promoting their maintenance or their differenciation (Gabut et al, Cell, 2. Pr. Our objective is to determine how alterations of stem cell splicing programs in cancer stem cells contribute to their tumorigenic capacities.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |